From Concept to a Validated 3D Model—Built Around Your Research

Accelerate your research with customized 3D cell culture models designed around your biological targets, experimental goals, and assay requirements. With over 10 years of 3D cell culture expertise and experience supporting more than 500 cell and tissue models, TheWell Bioscience helps researchers develop, optimize, and implement application-specific 3D workflows.

From organoids and tumoroids to disease models and complex co-culture systems, access expert support at every stage—from model development and validation to assay-ready culture plates and compound screening.

Start Your Project See how it Works

Choose Your 3D Research Solution

Flexible service options to match your research goal, from model development to screening.

Abstract illustration of several rounded cells with dark centers clustered together, outlined in blue.

3D Model Development Service

Custom, validated 3D models built for your research from feasibility studies to SOPs and functional data.  Establish a new model or adapt an existing one to your cell type or disease.

ScreenReady™ 3D Cell
Plate Service

Provide ready-to-use VitroPrime™ culture plates with your cells seeded, cultured, and QC’d, delivered assay-ready.

Skip the setup and receive plates ready to dose or image.

Compound Screening

Drug and compound screening in 3D, including IC50, dose-response, and combination
studies.

Generate efficacy or toxicity data in a physiologically relevant 3D model.

Find your model type

Start with an Existing Model or Build Your Own
You don’t always need to start from scratch. Tell us what model you need, and our scientists will first determine whether an established workflow can be adapted or whether a custom model is needed.

Begin with an existing model

Start faster with an established workflow. Many projects begin from a model we’ve already validated — adapted to your cell type, then extended. Ask us what’s ready now.

Develop a new model

Build a customized workflow for your application.
Cell/tissue selection → ECM optimization → media optimization → culture conditions → characterization → functional assay → SOP.

Find Your Model Type
Model categoryExamplesTypical applicationsAvailability
OrganoidsGastrointestinal, liver & pancreatic, kidney, neural, respiratory, reproductiveDisease modeling, differentiation, tissue biologyReady to start; Custom
Tumoroids & PDOsPatient-derived tumor organoids across multiple cancer typesEfficacy screening, patient-relevant oncologyReady to start; Custom
Disease-specificGlioblastoma (GBM), fibrosis, other disease modelsMechanism studies, targeted drug testingCustom
Invasion & migration3D invasion, migration, and EMT modelsMetastasis research, anti-invasion compound testingReady to start; Custom
SpheroidsTumor spheroids, MSC and stem-cell spheroidsHTS, viability and toxicity, aggregation studiesReady to start
Co-cultureTumor–immune, tumor–stroma, multi-cell-type systemsTumor microenvironment, immuno-oncologyCustom

How It works

1. Submit Your Inquiry

Tell us your cell/tissue type, application, desired model and research objective.

2. Meet with a 3D Expert

Our scientists review your requirements, current workflow and desired endpoints.

3. Establish and Validate

We develop or optimize matrix, media, culture format and relevant assays.

4. Receive Model & Report

Receive agreed deliverables: SOP, model/plates, characterization, screening data and/or report.

Start Your Project

Share your research goal and requirements. Our team will review your inquiry and recommend whether an existing model, a customized development project, the ScreenReady™ format, or a screening study is the best path.

3D Models on Demand
What support are your looking for?
What type of model are you interested in?
Do you already have cells/tissue?
What's your primary research goal?
Project Timeline

FAQ

No. The service can support a broad range of 3D models, including organoids, spheroids, tumoroids, invasion, co-culture, angiogenesis/vascular, stem-cell-derived, GBM/EMT and other customized systems.

Yes. The team can evaluate feasibility and define a customized development plan based on the cells/tissue, research objective and desired endpoints.

Yes. Existing workflows using animal-derived ECMs can be evaluated for transfer and optimization into a defined animal-origin-free workflow, when technically appropriate. The team can assess your current workflow, application requirements, and available materials to determine the most suitable approach.

Yes. You can provide your own cells or tissue for applicable projects. Accepted materials, shipping and handling requirements, and project-specific feasibility will be reviewed with the team before submission to ensure the material is suitable for the requested application..

Yes—route qualified projects to ScreenReady™ 3D Models.

Yes—position compound screening as the natural next step after model establishment, subject to project scope and assay feasibility.