Category Archives: Research Highlights

3D Bioprinting of an Implantable Xeno-free Vascularized Human Skin Graft

Institutions: Yale University School of Medicine and several other institutions Team: Baltazar T., Jiang B., Moncayo A., Merola J., Albanna M., Salzman W.M., and Pober, J.S. Application: Production of xeno-free bioink for 3D bioprinting of human skin cell grafts Disease Model: Human skin substitute Hydrogel: VitroGel® Hydrogel Matrix In many circumstances, bioengineered skin substitutes are […]

Inhibition of CDK7-dependent Transcriptional Addiction is a Potential Therapeutic Target in Synovial Sarcoma

Institutions: University of Miami, UCLA, USC, and the Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Team: Li X., Dean D.C., Yuan J., Temple T.H., Trent J.C., Rosenberg A.E., Yu, S., Hornicek F.J., and Duan, Z. Application: Mimicking the 3D tumor cell environment for cancer cell proliferation assays and therapeutic strategies […]

Enamel Matrix Derivative Enhances the Odontoblastic Differentiation of Dental Pulp Stem Cells via Activating MAPK Signaling Pathways

Institutions: Chinese Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, China Team: Zhang B., Xiao M., Cheng X., Yu B., Chen H., Yu Q., and Qiu, L. Application: Creating and injectable hydrogel for the tracking of dental pulp regeneration via stimulation of stem cells Disease Model: Dental pulp regeneration Hydrogel: VitroGel® RGD Dental […]

VitroGel® RGD Hydrogel Improves the Therapeutic Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Phosgene-Induced Acute Lung Injury in Rats

TheWell Bioscience VitroGel® RGD and VitroGel® 3D speed up how fast joints can repair themselves Institutions: Fudan University, Shanghai, China Team: Ding J., Sun Y., He D., Shao Y., Liu F., Zhang L., and Shen, J. Application: To aid mesenchymal stem cell culturing and delivery for the healing of lung tissue injury. Disease Model: Phosgene-induced […]

VitroGel® RGD-derivatized Hydrogels Can Support Cartilage Wound Healing

TheWell Bioscience VitroGel® RGD and VitroGel® 3D speed up how fast joints can repair themselves Institutions: Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Bolonga, Italy Team: Manferdini C., Trucco D., Saleh Y., Gabusi E., Dolzani P., Lenzi E., Vannozzi, L., Ricotti, L., and Lisignoli G. Application: To aid the healing process of damaged joint cartilage using […]

Centrosome Positioning in Migrating Dictyostelium Cells

  Institution: Ludwig Maximillian University, Munich, Germany Team: Ishikawa-Ankerhold H., Kroll J., van den Heuvel., Renkawitz J., and Müller-Taubenberger A. Application: New insight into how cells move through the environment in an amoeba-like fashion as sometimes occurs during wound healing. Disease Model: Wound healing Hydrogel: VitroGel® Hydrogel Matrix When cells move from one place to […]

A New Valid Rhabdomyosarcoma Spheroid Culture Model for in Vitro Evaluation of Hypericin-Based Photodynamic Therapy

Institution:University Hospital Marburg, Marburg, Germany Team:Hempfling L., Adamus A., Wagner B.R., Engel N., and Seitz, G. Application:Creation of a 3D cell culture scenario for the study of the efficacy of photodynamic therapy as an anti-cancer treatment. Disease Model:Pediatric alveolar rhabdomyosarcoma Hydrogel:VitroGel® RGD Photodynamic therapy (PDT) has shown promise in the treatment of certain malignancies that […]

Restraint Upon Embryonic Metatarsal Ex Vivo Growth by Hydrogel Reveals Interaction Between Quasi-Static Load and the mTOR Pathway

Institution:Royal Veterinary College, London Team:Caetano-Silva S., Simbi B.H., Marr N., Hibbert A., Allen S.P., and Pitsillides, A.A. Application:Creation of a cell culture environment that emulates a quasi-static load to test mechanical influences on limb growth. Disease Model:Mouse limb skeletal development Hydrogel:VitroGel® 3D The factors that control skeletal limb development in mammals are only partially understood. […]

Characterization of Lipopolysaccharide-Induced Prostate Cancer Formation and Possible Amelioration of This Process by the Antibiotic Trichostatin A

Institution:Affiliated Aoyang Hospital of Jiangsu University, Zhangjiagang, China Team:Tang S., Lian X., Cheng H., Guo J., Ni D., Huang C., Gu X., Meng H., Jiang J., and Li, X. Application:Establishment of a tissue-mimicking 3D cell culture to test tumor formation, progression, and inhibition in prostate cell lines. Disease Model:Prostate Cancer Hydrogel:VitroGel® RGD The progression of […]

Validation of Low-Intensity Pulsed Ultrasonic Systems That Can Modulate the Doses That Are Delivered to Biological Targets

Institution:The BioRobotics Institute, Pisa, Italy Team:Fontana F., Iberite F., Cafarelli A., Aliperta A., Baldi G., Gabusi E., Dolzani P., Cristo S., Lisignoli G., Pratellesi T., Dumont E., Jr., and Ricotti, L. Application:Addition of a microbiological growth environment to a low-intensity ultrasound chamber to test for external contamination. Disease Model:Ultrasound diagnostics Hydrogel:VitroGel® 3D Ultrasound (US) is […]