Category Archives: Research Highlights

A “Knockout” Antibody for White Blood Cell Studies

Institutions: University Medical Center Utrecht, The Netherlands Team: Olofsen, P.A., Stip, M.C., Marco Jansen, J.H., Chan, C., Nederend, M., Tieland, R.G., Tsioumpekou, M., and Leusen, J.H.W. Disease Model: Cancer Hydrogel: VitroGel® Hydrogel Matrix Neutrophils can be incapacitated with a new antibody, injected into mice with the help of VitroGel Hydrogel Matrix, and then assayed for […]

Cells: Prepare Yourself to Make Cartilage

Institutions:IRCCS Instituto Orthopedico Rizzoli, Bologna, Italy Team:Gabusi, E., Lenzi, E., Manferdini, C., Dolzani, P., Columbaro, M., Saleh, Y., and Lisignoli, G. Disease Model:Osteoarthritis Hydrogel:VitroGel® RGD Stem cells embedded in VitroGel Hydrogel 3G RGD matrix can display autophagy, allowing a critical examination of this process in the differentiation into healthy chondrocytes. When a cell starts to […]

Hydrogels and Light – A powerful Anticancer Duo

  Institutions:Shanghai Key Laboratory of Regulatory Biology and Tongji University, China Team:Yu, Y., Wu, X., Wang, M., Liu, W., Zhang, L., Zhang, Y., Hu, Z., Zhou, X., Jiang, Q., Cai, F., and Ye, H. Disease Model:Melanoma Hydrogel:VitroGel® 3D Engineered light-activated cytokine delivering cells can be encapsulated in VitroGel hydrogel for more efficient delivery to tissues […]

A Nurturing Matrix for Healing the Uterus

Institutions:Hospital of China Medical University and Key Laboratory of Reproductive Dysfunction Diseases and Fertility Remodeling, China Team:Hao, X., Zhang, S., Li, P., Huang, J., Yuan, Z., and Tan, J. Disease Model:Intrauterine adhesions Hydrogel:VitroGel® RGD The VitroGel RDG hydrogel matrix can assist the delivery of mesenchymal stem cells to treat intrauterine adhesions and prevent them from […]

Turn Me Off, Please!

Institutions: Guangzhou Medical University, China Team: Yang, F.M., Shen, L., Fan, D.D., Bai, Y., Li, B., and Lee, J. Disease Model: Inflammation Hydrogel: VitroGel® 3D Cells grown in 3D cell culture reveal how the inflammation pathway works, and what possible new protein variants can be designed to suppress TNF-induced inflammation. Inflammation, be it chronic or […]

The Sweet Spot for Liver Cell Culture

Institutions:National Institute for Nutrition and Health, China Team:Wang, J.B., Qin, W., Yang, Z., Ma, Y., Wang, L.Y., Zhou, Q., Gong, Z.L., Huo, J.S., and Chen, C. Disease Model:Liver Disease Hydrogel:VitroGel® RGD A rigorous statistical analysis of 3D cell culture conditions allowed researchers to fine-tune the optimal dilution, time, and starting cell concentration values for liver […]

HPGDS in Adipose‑Derived MSCs Can Speed Wound Healing in Type 2 Diabetes

Institutions:Peking Union Medical College, Beijing, China Team:Ouyang L., Qiu, D., Fu, X., Wu, A., Yang, P., Yang, Z., Wang, Q., Yan, L., and Xiao, R. Application:Wound Healing Disease Model:Type 2 Diabetes Hydrogel:VitroGel® RGD Overexpression of hematopoietic prostaglandin D synthase (HPGDS) in the wound tissue of mice with type 2 diabetes can reduce inflammation and speed […]

Knocking Down Doors to Find Cancer Therapies Using Anti-Kinase Strategies

Institutions:University of South China, The University of Miami, University of Southern Califormia, The Ohio State University, The Ohio State University Wexner Medical Center, and University of California Team:Cui, J., Dean, D., Hornicek, F.J., Pollock, R.E., Hoffman, R.M., and Duan, Z. Application:3D cell culture Disease Model:Liposarcoma Hydrogel:VitroGel® 3D The use of a 3D cell culture was […]

Shining a (near-infrared) Light to Find Cancer

Institutions:Shandong University and University of Jinan, China Team:Chen Y., Zhang X., Xiaoya L., Wu H., Zhang D., Zhu B., and Huang S. Application:HSC2 or CAL-27 cells in VitroGel xenografted into nude mice- identification of hypoxic levels in vivo Disease Model:Cancer progression and diagnosis Hydrogel:VitroGel® 3D Kit Cancer cells grown in VitroGel 3D can be detected […]

Check the MAP(K): Cancer Driver Signals on Pathway to Change Lanes

Institutions:Universitätsmedizin Berlin, and the German Cancer Consortium Team:Uhlitz F., Bischoff, P., Peidli, S., et al. Application:Cancer Research Disease Model:Colorectal Cancer Viability Analysis:Cyto3D Live-Dead Assay Kit Mitogen-activated protein kinases divert the normal developmental path in colorectal cells onto a road to cancer, and there are distinct RNA signals that reveal this change. The sequence of events […]