Xeno-Free Hydrogels for 3D Cell Culture Research

VitroGel® is a user-friendly xeno-free hydrogel for 3D cell culture.  Create advanced ECM in less than 20 minutes.

Xeno-Free Hydrogel

Room Temp Stable

Easy Cell Harvesting

Batch-to-Batch Consistency

High-Throughput Capable

Discover all the advantages

Application Notes - Research Highlights

A New Valid Rhabdomyosarcoma Spheroid Culture Model for in Vitro Evaluation of Hypericin-Based Photodynamic Therapy

Institution:University Hospital Marburg, Marburg, Germany Team:Hempfling L., Adamus A., Wagner B.R., Engel N., and Seitz, G. Application:Creation of a 3D cell culture scenario for the study of the efficacy of photodynamic therapy as [...]

Restraint Upon Embryonic Metatarsal Ex Vivo Growth by Hydrogel Reveals Interaction Between Quasi-Static Load and the mTOR Pathway

Institution:Royal Veterinary College, London Team:Caetano-Silva S., Simbi B.H., Marr N., Hibbert A., Allen S.P., and Pitsillides, A.A. Application:Creation of a cell culture environment that emulates a quasi-static load to test mechanical influences on [...]

Characterization of Lipopolysaccharide-Induced Prostate Cancer Formation and Possible Amelioration of This Process by the Antibiotic Trichostatin A

Institution:Affiliated Aoyang Hospital of Jiangsu University, Zhangjiagang, China Team:Tang S., Lian X., Cheng H., Guo J., Ni D., Huang C., Gu X., Meng H., Jiang J., and Li, X. Application:Establishment of a tissue-mimicking [...]

Validation of Low-Intensity Pulsed Ultrasonic Systems That Can Modulate the Doses That Are Delivered to Biological Targets

Institution:The BioRobotics Institute, Pisa, Italy Team:Fontana F., Iberite F., Cafarelli A., Aliperta A., Baldi G., Gabusi E., Dolzani P., Cristo S., Lisignoli G., Pratellesi T., Dumont E., Jr., and Ricotti, L. Application:Addition of [...]

Delivery of Cannabidiol via Extracellular Vesicles Improves the Cytotoxic Effects of Chemotherapy on Triple Negative Breast Cancer Cells

Institution:Florida State University Team:Patel N., Kommineni N., Surapaneni S.K., Kalvala A., Yuan X., Gebeyehu A., Arthur P., Duke L.C., York S.B., Bagde A., Meckes D.G., Jr., and Singh, M. Application:Creation of a 3D [...]

RNF208, an Estrogen-Inducible E3 Ligase, Targets Soluble Vimentin to Suppress Metastasis in Triple-Negative Breast Cancers

Institution:Seoul National University, Seoul, South Korea; Yonsei University Medical College, Seoul, South Korea; University of Tsukuba, Tsukuba, Japan; National Cancer Center Research Institute, Tokyo, Japan Team:Pang K., Park J., Ahn S.G., Lee J., [...]

Blebs Play an Important Role in Promoting Resistance to Programmed Cell Death in Metastatic Melanoma Cells

Institution: UT Southwestern Medical Center Team: Weems A.D., Welf E.S., Driscoll M.K., Mazloom-Farsibaf H., Chang B.-J., Weiss B.G., Chi J., Dean K.M., Fiolka R., and Danuser, G. Application: In vitro encapsulation of melanoma [...]

Estrogen Induces Apoptosis of Breast Cancer Cells in Aromatase Inhibitor Resistant Tumors

Institutions: 1. Department of Cancer Biology, Beckman Research Institute of the City of Hope, 2. Kyushu University, 3. Integrative Genomics Core, Beckman Research Institute of the City of Hope, 4. Department of Medical [...]

Conversion of Normal Cells to Pro-tumorigenic Lung Cancer Cells Can Occur by the Transfer of Micro RNAs From Circulating Extracellular Vesicles

Institution: Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy Team: Pontis F., Roz L., Mensah M., Segale M., Moro M., Bertolini G., Petraroia I., Centonze G., Ferretti A.M., Sautoni P., Pastorino U., Fortunato, [...]

Spheroid Invasion Assay With the Xeno-free, Bio-Functional VitroGel® Hydrogel Matrix

Application Note Nana-Fatima Haruna, John HuangTheWell Bioscience, North Brunswick, NJ 08902 Introduction Cell migration and invasion play important roles in various physiological processes such as gastrulation, embryonic morphogenesis, development of the nervous system, [...]

Glucose Metabolism in Obese Mice can be Improved by Implantation with Photoactivated Adipose Stem Cells

Institution: Southwest Medical University, Luzhou, Sichuan, China Team: Zhu L., Feng Z., Shu X., Gao Q., Wu J., Du Z., Li R., Wang L., Chen N., Li Y., Luo M., and Wu J. [...]

Establishing the First Co-Culture Model of Human Gastric Organoids and Dendritic Cells Using the Xeno-free VitroGel ORGANOID Hydrogel

Institutions: Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States Team: Michelle D. Chergne, Barkan Sidar, T. Andrew Sebrell, Humberto S. Sanchez, Kody Heaton, Francis J. Kassama, Mandi M. [...]

New hPSCs Expansion Method – Direct from Liquid Nitrogen to 3D Culture Using a Xeno-free Hydrogel – VitroGel® STEM

Culturing and maintaining human pluripotent stem cells (hPSCs) directly from cryopreservation using the xeno-free, hydrogel-based VitroGel® STEM Application Note TheWell Bioscience, North Brunswick, NJ 08902 Introduction Due to the advent of stem cell [...]

Identification of a Novel Antitumor Small-Molecule Known as MKI-1 via Activation of PP2A in Breast Cancer

Institutions:Korea Institute of Radiological and Medical Sciences, Seoul, South Korea; Radiological and Medico-Oncological Sciences, University of Science and Technology, Daejeon, South Korea; Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea; New Drug [...]

miR-340 Restoration Promotes Macrophage Phagocytosis and Antitumor Immunity via Regulation of CD47 Expression

Institutions: Tianjin Medical University, Tianjin, China; Guangdong Pharmaceutical University, Guangzhou, China; University of Texas Southwestern Medical Center, Dallas, Texas, USA. Team: Xi q., Zhang J., Yang G., Zhang L., Chen Y., Wang C., [...]

News & Events

ISSCR 2022 – International Society for Stem Cell Research

TheWell Bioscience is excited to be exhibiting at ISSCR 2022 (International Society for Stem Cell [...]

Patient-Derived Tumoroids in 3D Xeno-Free Hydrogel with Automated Biomarker Detection

Abstract 3D cell models like organoid and patient-derived tumoroid are becoming increasingly important for personalized [...]

AACR 2022 – American Association for Cancer Research

TheWell Bioscience is excited to be exhibiting at AACR 2022 (American Association for Cancer Research) [...]

Society for Laboratory Automation and Screening 2022

TheWell Bioscience is excited to be exhibiting at SLAS (Society for Laboratory Automation and Screening) [...]

Standard for Measuring Cell Viability in Scaffolds

We are excited that our VitroGel®, a xeno-free hydrogel system, is part of the National [...]