Xeno-Free Hydrogels for 3D Cell Culture Research

VitroGel® is a user-friendly xeno-free hydrogel for 3D cell culture.  Create advanced ECM in less than 20 minutes.

Xeno-free hydrogel

Room temp stable

Easy cell harvesting

Batch-to-Batch Consistency

High-Throughput Capable

Discover all the advantages

Research Highlights - Application NOTES

Cyclin-dependent kinase 7 (CDK7) Overexpression Implicated as an Independent Predictor of Poor Prognosis of Osteosarcoma

Institution: Department of Orthopedic Surgery at UCLA Team: Hangzhan Ma, Dylan C. Dean, Ran Wei, Francis J. Hornicek and Zhenfeng Duan Application: 3D culture to evaluate the effects of CDK7 in an in [...]

3D Printed Tumor Spheroids for Disease Modeling and Chemotherapeutic Drug Screening

Institution: Florida A&M University Team: Aragaw Gebeyehu1,4, Sunil Kumar Surapaneni1,4, John Huang2, Arindam Mondal1, Vivian Ziwen Wang2, Nana Fatima Haruna2, Arvind Bagde1, Peggy Arthur1, Shallu Kutlehria1, Nil Patel1, Arun K. Rishi3 & Mandip [...]

3D Invasion of Glioblastoma Cells in VitroGel Hydrogel System

Application Note Nana-Fatima Haruna, John Huang TheWell Bioscience, North Brunswick, NJ 08902 Introduction Glioblastoma is the most common primary tumor in the central nervous system. With an incidence of 3–5 out of 100,000 [...]

Using the VitroGel Hydrogel System as a Versatile Platform for Invasion Assay

Application Note Nana-Fatima Haruna, Atsuo Ochi, John Huang TheWell Bioscience, North Brunswick, NJ 08902 Introduction Invasion studies have been crucial in identifying key intracellular signaling pathways and membrane-bound and soluble enzymes that influence [...]

Targeting Gangliosides for Melanoma Brain Metastasis Treatment

In vitro three-dimensional analysis elucidates the role of cell surface GD3 ganglioside and ST8SIA1 in melanoma brain metastasis. Institution: John Wayne Cancer Institute (JWCI), Fudan University, Providence St. Joseph Health Center, Tel-Aviv University, [...]

Penetrating Cancer Stem Cells For Lung Cancer Treatment

Scientists from Florida A&M University have discovered the ability of Tel and DXTPL combination system to increase the power of DXTPL to penetrate cancer stem cells and decrease the chances of cancer relapse [...]

Silent Partner: The MYC-related pseudogene HMGA1P6 drives malignancy in ovarian cancer

In vitro three-dimensional culture helps to demonstrate that several pseudogenes, including HMGA1P6, are involved in metastasis of ovarian cancer, introducing another unconventional target for cancer therapeutics. Institution: Shandong University Team: Xiaoxue Tian, Jianping [...]

The injectable VitroGel provides a viable in vivo scaffold for novel maternal-fetal adipose stem cell transplant studies

Maternally derived adipose stem cells have emerged as a possible solution to the common immunological rejection observed in fetal repair surgeries. Institution: Showa University School of Medicine Team: Akihiro Kawashima*, Rika Yasuhara, Ryosuke [...]

VitroGel’s ability to enhance the ECM-cell interaction enhances transplantable capacity of MSCs in rat models of intervertebral disc regeneration

VitroGel® RGD enhances stem cell transplantation to treat intervertebral disc degeneration using rat models, laying new foundations in the movement toward cell-based tissue therapies. Institution: Dalian Medical University, Clinical Medical College of Yangzhou [...]

Defrosting Fertility: VitroGel offers a viable alternative to ovarian tissue cryopreservation

In vitro three-dimensional culture of murine ovarian follicles in the VitroGel demonstrates superior morphology and growth compared to other biomaterials and 2D culture. Institution: Seoul National University, Eulji University Team: Eun Jung Kim, [...]

One step closer: ADK-L as a potential therapeutic target for aggressive metastatic breast cancer

Manipulation of the adenosine metabolite ADK-L may offer a way to modulate cell invasion and proliferation of breast cancer cells, offering a possible therapeutic solution to aggressive breast cancers. Institution: Legacy Research Institute, [...]

Breakdown in Communication: Extracellular Vesicles Drive Lung Cancer Progression by Shuttling c-Myc

Cancer cell-derived and plasma-derived oncogenic extracellular vesicles uniquely carry the cell cycle activator c-Myc and promote cell cycle upregulation and cluster formation of healthy cells in a 3D microenvironment. Institution: Fondazione IRCCS Istituto [...]

OSA 1777: A New Tool in the Fight Against Bone Cancer

Introducing OSA 1777, a cell line derived from recurring osteosarcoma, which unlike existing cell lines, forms spheroids in 3D culture reminiscent of osteosarcoma tumors. Institution: David Geffen School of Medicine, University of California, [...]

A New Weapon Against an Old Foe: PPM1D Inhibitors Are a Promising New Treatment for a Deadly Childhood Brain Tumor

New mechanistic insights into the tumorigenesis of DIPG yield a novel potential treatment: PPM1D inhibitors Institution: Emory School of Medicine Team: Mwangala Precious Akamandisa, Kai Nie, Rita Nahta, Dolores Hambardzumyan, and Robert Craig [...]

3D Printed Tumor Spheroids for Disease Modeling and Chemotherapeutic Drug Screening

Poster Presentation TheWell Bioscience Inc. Aragaw Gebeyehu1, Sunil Surapaneni1, John Huang2, Arindam Mondal1, Vivian Wang2, Nana-Fatima Haruna2, Peggy Arthur1, Shallu Kutlehria1, Nil Patel1, Mandip Sachdeva1 1College of Pharmacy and Pharmaceutical Sciences, Florida A&M [...]

News & Events

GHP Healthcare & Pharmaceutical Awards – Most Innovative 3D Hydrogel System 2020

GHP Magazine has Announced the Winners of the 2020 Healthcare & Pharmaceutical Awards Excited to [...]

TheWell Bioscience is recognized in “8 Top 3D Bioprinting Startups in Biotech”

Proud to be recognized as one of the “8 Top 3D Bioprinting Startups in Biotech”. [...]

ARMI Member Spotlight

We are excited to be a part of the ARMI BioFabUSA program. We look forward [...]

TheWell Bioscience Launches A New Generation of Bioinks for 3D Bioprinting

North Brunswick, NJ., January 16, 2020 – TheWell Bioscience Inc, a biotech company focusing on [...]

American Society for Cell Biology (ASCB 2019)

Our team is excited to exhibit at this year’s ASCB 2019 in Washington, D.C. We [...]