Xeno-Free Hydrogels for 3D Cell Culture Research

VitroGel® is a user-friendly xeno-free hydrogel for 3D cell culture.  Create advanced ECM in less than 20 minutes.

Xeno-Free Hydrogel

Room Temp Stable

Easy Cell Harvesting

Batch-to-Batch Consistency

High-Throughput Capable

Discover all the advantages

Research Highlights - Application NOTES

Advanced 3D Luminal Breast Cancer Model in VitroGel® System: Long-term 3D Cell Culture and Co-culture with Fibroblast Cells

Application Note Nana-Fatima Haruna, Bhavya Shah,John Huang TheWell Bioscience, North Brunswick, NJ 08902 Introduction There is an increasing need for the generation of data that accurately reflects the biological systems of patients 1-3. [...]

Targeting Soluble Vimentin to Suppress Metastatic Breast Cancer Models In Vivo and In Vitro

Institution: Precision Medicine Research Center, Seoul National University Team: Pang, K., Park, J., Ahn, S. G., Lee, J., Park, Y., Ooshima, A., Mizuno, S., Yamashita, S., Park, K.-S., Lee, S.-Y., Jeong, J., Ushijima, [...]

Comparison between 2D and 3D Cell Cultured Adipose-derived Mesenchymal Stem Cells

Institution: Cancer Center at the First Hospital of Jilin University Team: Qiliang Yin, Na Xu, Dongsheng Xu , Mingxin Dong, Xiumin Shi, Yan Wang, Zhuo Hao, Shuangshuang Zhu, Donghai Zhao, Haofan Jin, and [...]

ovarian cancer study
ATR and phospho-ATR ser428 (p-ATR) Expression in Ovarian Cancer Prognosis

Institution: The First Affiliated Hospital of Zhengzhou University David Geffen School of Medicine at UCLA Team: Wenlong Feng, Dylan C. Dean, Francis J. Hornicek, Jinglu Wang, Yanyan Jia, Zhenfeng Duan, and Huirong Shi [...]

VitroGel Hydrogel Used to Bridge the Gap Between In Vivo and In Vitro Pancreatic Islet Beta-cells Studies

Institution: Xiamen Medical College Team: Tianshu Lan, Jingyi Guo, Xiaoming Bai, Zengjiong Huang, Zhimin Wei, Guicheng Du, GuoliangYan, Lebin Weng, Xue Yi Application: Development of 3D islet pancreatic beta-cells (β-cells) Disease Model: The [...]

Inhibition of Scar Proliferation with In-situ Cross Bonding of VitroGel Hydrogel and Adipose-derived Stem Cells Conditioned Medium

Institution: Fujian Medical University Team: Chaoyu Zhang, Ting Wang, Li Zhang, Penghong Chen, Shijie Tang, Aizhen Chen, Ming Li, Guohao Peng, Hangqi Gao, Haiyan Weng, Haoruo Zhang, Shirong Li, Jinghua Chen, Liangwan Chen, [...]

Development of Hypoxic-Responsive Lipid Polymer Nanoparticle for Eradication of Residual Glioma Cells

Institution: Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou Team: Haoyue Xu, Yuhan Han, Gang Zhao, Long Zhang, Zongren Zhao, Zhen Wang, Liang Zhao, Lei Hua, Konduru Naveena, Jun Lu, Rutong Yu, [...]

Long Term 3D Tumor Spheroid Culture in VitroGel Hydrogel Matrix

Application Note Nana-Fatima Haruna, Bhavya Shah, John Huang TheWell Bioscience, North Brunswick, NJ 08902 Introduction Cancer is a very meticulous disease that involves heterogeneous solid tumors subjected to complex extracellular conditions. These conditions, [...]

Cyclin-dependent kinase 7 (CDK7) Overexpression Implicated as an Independent Predictor of Poor Prognosis of Osteosarcoma

Institution: Department of Orthopedic Surgery at UCLA Team: Hangzhan Ma, Dylan C. Dean, Ran Wei, Francis J. Hornicek and Zhenfeng Duan Application: 3D culture to evaluate the effects of CDK7 in an in [...]

3D Printed Tumor Spheroids for Disease Modeling and Chemotherapeutic Drug Screening

Institution: Florida A&M University Team: Aragaw Gebeyehu1,4, Sunil Kumar Surapaneni1,4, John Huang2, Arindam Mondal1, Vivian Ziwen Wang2, Nana Fatima Haruna2, Arvind Bagde1, Peggy Arthur1, Shallu Kutlehria1, Nil Patel1, Arun K. Rishi3 & Mandip [...]

3D Invasion of Glioblastoma Cells in VitroGel Hydrogel System

Application Note Nana-Fatima Haruna, John Huang TheWell Bioscience, North Brunswick, NJ 08902 Introduction Glioblastoma is the most common primary tumor in the central nervous system. With an incidence of 3–5 out of 100,000 [...]

Using the VitroGel Hydrogel System as a Versatile Platform for Invasion Assay

Application Note Nana-Fatima Haruna, Atsuo Ochi, John Huang TheWell Bioscience, North Brunswick, NJ 08902 Introduction Invasion studies have been crucial in identifying key intracellular signaling pathways and membrane-bound and soluble enzymes that influence [...]

Targeting Gangliosides for Melanoma Brain Metastasis Treatment

In vitro three-dimensional analysis elucidates the role of cell surface GD3 ganglioside and ST8SIA1 in melanoma brain metastasis. Institution: John Wayne Cancer Institute (JWCI), Fudan University, Providence St. Joseph Health Center, Tel-Aviv University, [...]

Penetrating Cancer Stem Cells For Lung Cancer Treatment

Scientists from Florida A&M University have discovered the ability of Tel and DXTPL combination system to increase the power of DXTPL to penetrate cancer stem cells and decrease the chances of cancer relapse [...]

Silent Partner: The MYC-related pseudogene HMGA1P6 drives malignancy in ovarian cancer

In vitro three-dimensional culture helps to demonstrate that several pseudogenes, including HMGA1P6, are involved in metastasis of ovarian cancer, introducing another unconventional target for cancer therapeutics. Institution: Shandong University Team: Xiaoxue Tian, Jianping [...]

News & Events

Measuring Cell Viability in Scaffolds

We are excited that our VitroGel®, a xeno-free hydrogel system, is part of the National [...]

GHP Healthcare & Pharmaceutical Awards – Most Innovative 3D Hydrogel System 2020

GHP Magazine has Announced the Winners of the 2020 Healthcare & Pharmaceutical Awards Excited to [...]

TheWell Bioscience is recognized in “8 Top 3D Bioprinting Startups in Biotech”

Proud to be recognized as one of the “8 Top 3D Bioprinting Startups in Biotech”. [...]

ARMI Member Spotlight

We are excited to be a part of the ARMI BioFabUSA program. We look forward [...]

TheWell Bioscience Launches A New Generation of Bioinks for 3D Bioprinting

North Brunswick, NJ., January 16, 2020 – TheWell Bioscience Inc, a biotech company focusing on [...]