Xeno-Free Hydrogels for 3D Cell Culture

Over 225+ publications and references.

VitroGel® is a biofunctional animal-free hydrogel for 3D cell culture.  Achieve 3D cell culture assays in less than 20 minutes with consistent results.

Xeno-Free Hydrogel

Room Temp Stable

Easy Cell Harvesting

Lot-to-Lot Consistency

Adaptable for
High-Throughput

APPLICATION NOTESRESEARCH HIGHLIGHTS

Game Changer for Lymphoma Therapy Screening

VitroGel® RGD played a key role in preserving tumor architecture for effective drug testing in lymphoma research   Institutions: Swiss Institute for Experimental Cancer Research, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland [...]

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Prolonged Dexamethasone Delivery Using VitroGel® for Protection Against Cisplatin-Induced Ototoxicity

VitroGel® significantly enhanced the delivery of dexamethasone to the inner ear, providing controlled release and improved protection against cisplatin-induced hearing loss.   Institutions:“Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania Team:Maximilian G. [...]

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Harnessing Patient-Derived Organoids to Decode Immunotherapy Responses in Colorectal Cancer

VitroGel® revolutionizes colorectal cancer research by creating a xeno-free platform for patient-derived organoids, enabling groundbreaking insights into tumor-immune interactions and immunotherapy responses.   Institutions:Fondazione Policlinico A. Gemelli IRCCS, Rome Team:Alice Dini, Harlan Carmine [...]

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VitroGel® ORGANOID Unlocks Precision High-Throughput Drug Screening Insights in Ovarian Cancer

VitroGel® ORGANOID empowered breakthrough single-cell pharmacotranscriptomic profiling by enabling robust, patient-specific cancer organoid models for drug discovery and resistance analysis.   Institutions: Disease Networks Unit, Faculty of Biochemistry and Molecular Medicine, University of [...]

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VitroGel® ORGANOID Reveals Unique Pathway Shifts in HOSE Cells Exposed to Tumor Microenvironment

VitroGel® ORGANOID-4 deepened ovarian cancer research by allowing 3D spheroid formation and transcriptomic analysis, identifying key signaling STAT1 and GREM1 activation pathways. Institutions:University of Oulu; Institute for Molecular Medicine Finland; University of Helsinki; [...]

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Targeting System Xc− : A Novel Approach to Inhibit Glioblastoma Invasion

VitroGel® Hydrogel Matrix provided a realistic three-dimensional environment for studying Glioblastoma invasion behavior. Institution:Department of Biological Science, Chungnam National University  Team:Jiyoon Baik, Myunghoon Lee, Jae Hong Yoo, Ahyeon Jo, Kyung-Seok Han Category:3D Cell Models & Functional Assay Subcategory/cell type:Invasion [...]

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Decoding New Insights into DCLK1’s Role in Cancer Cell Invasion and ECM Degradation

VitroGel® Hydrogel Matrix was used to establish mobility, gelatinase activity, protein-protein interaction, and invasion assays to unravel the underlying mechanisms behind the invasiveness of Head and Neck Squamous Cell Carcinoma (HNSCC).  Institutions:University of [...]

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miR-34b-5p: A New Hope in Endometrial Cancer Treatment

Institutions:School of Clinical Medicine, Ningxia Medical University Team:Lulu Shi, Dan Yang, Hui Dong, Xueyu Zhang, Caihong Yang Disease Model:3D Cell Models & Functional Assay Subcategory/cell type:Invasion assay/human endometrial cancer AN3CA cells Hydrogel: VitroGel® Hydrogel [...]

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A Novel Pre-Clinical Model of the Normal Human Breast

Institutions:Manchester Cancer Research Centre, University of Manchester Team:Anthony J. Wilby, Sara Cabral, Nastaran Zoghi, Sacha J. Howell, Gillian Farnie, and Hannah Harrison Disease Model:3D Cell Models & Functional Assay Subcategory / Tissue Type:ex vivo models / human breast tissue Hydrogel:VitroGel® RGD VitroGel® [...]

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Tracking Down the Culprit Responsible For AML

Institutions:Jilin University, China Team:Liu, M., Yu, B., Tian, Y., and Li, F. Disease Model:Acute Myeloid Leukemia Hydrogel:VitroGel® RGD A combination of a gene expression network analysis and in vitro assays implicates regulation and [...]

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COPD-Linked Extracellular Vesicles Transfer HIF-1α, Fueling Lung Cancer

Institutions:Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy Team:Petraroia, I., Ghidotti, P., Bertolini, G., Pontis, F., Roz, L., Balsamo, M., Suatoni, P., Pastorino, U., Ferretti, A.M., Sozzi, G., & Fortunato, O. Disease Model:Chronic [...]

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Utilizing Ultrasound Waves with Embedded Mesenchymal Stromal Cell in VitroGel® for Cartilage Regeneration

Institutions:The BioRobotics Institute and Department of Excellence in Robotics & AI, Scuola Superiore Sant’Anna, Pisa, Italy; and several other European institutions Team:Ricotti, L., Cafarelli, A., Manferdini, C., et al. & Lisignoli, G. Disease [...]

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Cyto3D® Live-Dead Assay Kit Aids in Identifying MiRNAs as Promising Biomarkers for Glioma Prognosis

Institutions: Translational Oncology Research Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.; and several other Italian institutions Team: Méndez, A.B.D., Sacconi, A., Tremante, E., et al. & Rizzo, M.G. Disease Model: Brain [...]

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Quick and Efficient Organoid/Cell Recovery from Animal-Based Extracellular Matrix

Introduction Contemporary hydrogel matrices provide enormous advantages for two- and three-dimensional cell culturing. They provide an environment that mimics that of natural tissue, increasing growth rates and offering conditions in which native in [...]

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The Good Side of Bad Cholesterol

Institutions: University Hospital Regensburg, Germany Team: Babl, N., Hofbauer, J., Matos, C., Voll, F., Menevse, A.N., Rechenmacher, M., Mair, R., Beckhove, P., Herr, W., Siska, P.J., Renner, K., Kreutz, M., & Schnell, A. [...]

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News & Events

Revolutionizing Cartilage Repair: Combining the VitroGel® System with a Bendable-Tip Arthroscopic Device for Controlled Hydrogel Extrusion

VitroGel® Hydrogel for In Vivo / Tissue Engineering  Revolutionizing Cartilage Repair: Combining the VitroGel® System [...]

Regemat 3D to Distribute VitroINK® Bioinks: A Strategic Distribution for Advanced Bioprinting Solutions in Europe

Monmouth Junction, NJ | February 20, 2025 — TheWell Bioscience Inc., a leading biotech company [...]

Lymphomoids: A Tissue-based Ex Vivo Culture System for Lymphoma Therapy Screening

VitroGel® Hydrogel for Ex Vivo/Tissue Explant Models Lymphomoids: A Tissue-based Ex Vivo Culture System for [...]

2024 in Review: TheWell Bioscience Milestones, Growth, and Vision for 2025

2024 in Review: TheWell Bioscience Milestones, Growth, and Vision for 2025 We’re excited to celebrate [...]

TheWell Bioscience 2024 Innovations for Advancing 3D Cell Culture

2024 Innovations for Advancing 3D Cell Culture This year has marked remarkable growth and innovation [...]

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