Category Archives: Research Highlight

Cyclin-dependent kinase 7 (CDK7) Overexpression Implicated as an Independent Predictor of Poor Prognosis of Osteosarcoma

Institution: Department of Orthopedic Surgery at UCLA Team: Hangzhan Ma, Dylan C. Dean, Ran Wei, Francis J. Hornicek and Zhenfeng Duan Application: 3D culture to evaluate the effects of CDK7 in an in vivo environment Disease Model: Osteosarcoma Hydrogel: VitroGel® 3D Osteosarcoma is the most common primary tumor of bone and accounts for 35% of […]

3D Printed Tumor Spheroids for Disease Modeling and Chemotherapeutic Drug Screening

Institution: Florida A&M University Team: Aragaw Gebeyehu1,4, Sunil Kumar Surapaneni1,4, John Huang2, Arindam Mondal1, Vivian Ziwen Wang2, Nana Fatima Haruna2, Arvind Bagde1, Peggy Arthur1, Shallu Kutlehria1, Nil Patel1, Arun K. Rishi3 & Mandip Singh1* Application:  3D bioprint of cancer cell lines to perform drug testings. Cell types: NSCLC-PDX, MDA MB231 WT, and HCC B-27 cells […]

Targeting Gangliosides for Melanoma Brain Metastasis Treatment

In vitro three-dimensional analysis elucidates the role of cell surface GD3 ganglioside and ST8SIA1 in melanoma brain metastasis. Institution: John Wayne Cancer Institute (JWCI), Fudan University, Providence St. Joseph Health Center, Tel-Aviv University, The University of Texas MD Anderson Cancer Center, Oregon Health and Science University (OHSU) Knight Cancer Institute Portland Team: Romela Irene Ramos, […]

Penetrating Cancer Stem Cells For Lung Cancer Treatment

Scientists from Florida A&M University have discovered the ability of Tel and DXTPL combination system to increase the power of DXTPL to penetrate cancer stem cells and decrease the chances of cancer relapse and metastasis. Institution: Florida A&M University Team: Peggy Arthur, Nilkumar Patel, Sunil Kumar Surapaneni, Arindam Mondal, Aragaw Gebeyehu, Arvind Bagde, Shallu Kutlehria, […]

Silent Partner: The MYC-related pseudogene HMGA1P6 drives malignancy in ovarian cancer

In vitro three-dimensional culture helps to demonstrate that several pseudogenes, including HMGA1P6, are involved in metastasis of ovarian cancer, introducing another unconventional target for cancer therapeutics. Institution: Shandong University Team: Xiaoxue Tian, Jianping Song, Xiyu Zhang, Mingyao Yan, Shourong Wang, Yuqiong Wang, Limei Xu, Ling Zhao, Jian-jun Wei, Changshun Shao, Beihua Kong *, and Zhaojian […]

The injectable VitroGel provides a viable in vivo scaffold for novel maternal-fetal adipose stem cell transplant studies

Maternally derived adipose stem cells have emerged as a possible solution to the common immunological rejection observed in fetal repair surgeries. Institution: Showa University School of Medicine Team: Akihiro Kawashima*, Rika Yasuhara, Ryosuke Akino, Kenji Mishima, Michiko Nasu, Akihiko Sekizawa Application: In vivo utilization of VitroGel RGD to study neuronal differentiation capacity Disease model: Neurometabolic […]

VitroGel’s ability to enhance the ECM-cell interaction enhances transplantable capacity of MSCs in rat models of intervertebral disc regeneration

VitroGel® RGD enhances stem cell transplantation to treat intervertebral disc degeneration using rat models, laying new foundations in the movement toward cell-based tissue therapies. Institution: Dalian Medical University, Clinical Medical College of Yangzhou University Team: Feng Wang, Li-ping Nan, Shi-feng Zhou, Yang Liu, Ze-yu Wang, Jing-cheng Wang, Xin-min Feng *, and Liang Zhang Application: 3D […]

Defrosting Fertility: VitroGel offers a viable alternative to ovarian tissue cryopreservation

In vitro three-dimensional culture of murine ovarian follicles in the VitroGel demonstrates superior morphology and growth compared to other biomaterials and 2D culture. Institution: Seoul National University, Eulji University Team: Eun Jung Kim, Chungmo Yang, Jaewang Lee, Hye Won Youm, Jung Ryeol Lee *, Chang Suk Suh, Seok Hyun Kim Application: 3D follicle culture Disease […]

One step closer: ADK-L as a potential therapeutic target for aggressive metastatic breast cancer

Manipulation of the adenosine metabolite ADK-L may offer a way to modulate cell invasion and proliferation of breast cancer cells, offering a possible therapeutic solution to aggressive breast cancers. Institution: Legacy Research Institute, Mid-Columbia Medical Center Team: Bahar Shamloo*, Nandita Kumar, Randall H. Owen, Jesica Reemmer, John Ost, R. Serene Perkins, and Hai-Ying Shen* Application: […]

Breakdown in Communication: Extracellular Vesicles Drive Lung Cancer Progression by Shuttling c-Myc

Cancer cell-derived and plasma-derived oncogenic extracellular vesicles uniquely carry the cell cycle activator c-Myc and promote cell cycle upregulation and cluster formation of healthy cells in a 3D microenvironment. Institution: Fondazione IRCCS Istituto Nazionale dei Tumori, Istituto di scienze e tecnologie Molecolari CNR Team: Cristina Borzi, Linda Calzolari, Anna M. Ferretti, Laura Caleca, Ugo Pastorino, […]