Category Archives: Research Highlight

Identification of a Novel Antitumor Small-Molecule Known as MKI-1 via Activation of PP2A in Breast Cancer

Institutions:Korea Institute of Radiological and Medical Sciences, Seoul, South Korea; Radiological and Medico-Oncological Sciences, University of Science and Technology, Daejeon, South Korea; Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea; Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Daejeon, South Korea […]

miR-340 Restoration Promotes Macrophage Phagocytosis and Antitumor Immunity via Regulation of CD47 Expression

Institutions: Tianjin Medical University, Tianjin, China; Guangdong Pharmaceutical University, Guangzhou, China; University of Texas Southwestern Medical Center, Dallas, Texas, USA. Team: Xi q., Zhang J., Yang G., Zhang L., Chen Y., Wang C., Zhang Z., Guo X., Zhao J., Xue Z., Li Y., Zhang Q., Da Y., Liu L., Yao Z., and Zhang R. Application: […]

KLF7: Discovery of a Novel Therapeutic Target and Biomarker for High-Grade Serous Ovarian Cancer

Institution: Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Milan, Italy Team:De Donato M., Babini G., Mozzetti S., Buttarelli M., Ciucci A., Arduini G., De Rosa M. C., Scambia G., Gallo D. Application:Discovery of KLF7, a novel biomarker and therapeutic target for high-grade serous ovarian cancer Disease Model:Ovarian Cancer Hydrogel:VitroGel® […]

Mesenchymal Stromal Cell-Derived CXCL12 Affects Tumor Growth by Macrophage M1 to M2 Polarization

Institution: Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Team:Babazadeh S., Nassiri S. M., Siavashi V., Sahlabadi M., Hajinasrollah M., and Zamani-Ahmadmahmudi Z. Application:Identification of a new role for MSC-derived CXCL12 in M2 phenotypic switching of macrophages, affecting tumorigenesis in breast cancer cells Disease Model:Breast Cancer Hydrogel:VitroGel® RGD Studies over […]

New Findings Elucidate BMP4 and Decellularized Pulp Extracellular Matrix Synergy to Accelerate Tissue Formation by Stem Cells

Institution: Stomatological Hospital of Chongqing Medical University, Chongqing Medical University. People’s Republic of China Team:Tan Q., Cao Y., Zheng X., Peng M., Huang E., and Wang J. Application:Identification of a novel synergistic relationship between BMP4 and dECM to accelerate pulp-like tissue formation by DPSCs in vitro Disease Model:Dental pulp stromal cells Hydrogel:VitroGel® 3D Young, permanent […]

Targeting Soluble Vimentin to Suppress Metastatic Breast Cancer Models In Vivo and In Vitro

Institution: Precision Medicine Research Center, Seoul National University Team: Pang, K., Park, J., Ahn, S. G., Lee, J., Park, Y., Ooshima, A., Mizuno, S., Yamashita, S., Park, K.-S., Lee, S.-Y., Jeong, J., Ushijima, T., Yang, K.-M., & Kim, S.-J. Application: Targeting Vimentin to suppress metastasis breast cancer Disease Model: Breast Cancer Hydrogel: VitroGel® 3D Among […]

Comparison between 2D and 3D Cell Cultured Adipose-derived Mesenchymal Stem Cells

Institution: Cancer Center at the First Hospital of Jilin University Team: Qiliang Yin, Na Xu, Dongsheng Xu , Mingxin Dong, Xiumin Shi, Yan Wang, Zhuo Hao, Shuangshuang Zhu, Donghai Zhao, Haofan Jin, and Wensen Liu Application: In vitro models of adipose-derived mesenchymal stem cells Disease Model: Adipose-derived mesenchymal stem cells (ADMSCs) Hydrogel: VitroGel® RGD In recent […]

ATR and phospho-ATR ser428 (p-ATR) Expression in Ovarian Cancer Prognosis

ovarian cancer study

Institution: The First Affiliated Hospital of Zhengzhou University David Geffen School of Medicine at UCLA Team: Wenlong Feng, Dylan C. Dean, Francis J. Hornicek, Jinglu Wang, Yanyan Jia, Zhenfeng Duan, and Huirong Shi Application: Studying the relationship of ATR and p-ATR in 3D ovarian cancer models Disease Model: Ovarian Cancer Cell Lines Hydrogel: VitroGel® 3D […]

VitroGel Hydrogel Used to Bridge the Gap Between In Vivo and In Vitro Pancreatic Islet Beta-cells Studies

Institution: Xiamen Medical College Team: Tianshu Lan, Jingyi Guo, Xiaoming Bai, Zengjiong Huang, Zhimin Wei, Guicheng Du, GuoliangYan, Lebin Weng, Xue Yi Application: Development of 3D islet pancreatic beta-cells (β-cells) Disease Model: The mouse β islet cell line, β-TC-6 Hydrogels: VitroGel® RGD, VitroGel® 3D, VitroGel® Cell Recovery Solution Islet transplantation is currently the only firmly […]

Inhibition of Scar Proliferation with In-situ Cross Bonding of VitroGel Hydrogel and Adipose-derived Stem Cells Conditioned Medium

Institution: Fujian Medical University Team: Chaoyu Zhang, Ting Wang, Li Zhang, Penghong Chen, Shijie Tang, Aizhen Chen, Ming Li, Guohao Peng, Hangqi Gao, Haiyan Weng, Haoruo Zhang, Shirong Li, Jinghua Chen, Liangwan Chen, Xiaosong Chen Application: Developing ADSCC-CM and VitroGel hydrogel complex to study hypertrophic scar prophylaxis Disease Model: Adipose-derived stem cells Hydrogel: VitroGel® RGD […]